{"id":720,"date":"2025-01-26T07:02:17","date_gmt":"2025-01-26T07:02:17","guid":{"rendered":"http:\/\/interrogacao.org\/?p=720"},"modified":"2025-01-26T07:02:17","modified_gmt":"2025-01-26T07:02:17","slug":"data-on-sociodemographic-characteristics-results-of-pcr-testing-and-vaccination-status-including-date-of-vaccination-doses-and-type-were-either-abstracted-from-medical-surveillance-record","status":"publish","type":"post","link":"https:\/\/interrogacao.org\/?p=720","title":{"rendered":"\ufeffData on sociodemographic characteristics, results of PCR testing, and vaccination status, including date of vaccination doses and type, were either abstracted from medical surveillance records or collected using questionnaires or ongoing loco-regional databases"},"content":{"rendered":"

\ufeffData on sociodemographic characteristics, results of PCR testing, and vaccination status, including date of vaccination doses and type, were either abstracted from medical surveillance records or collected using questionnaires or ongoing loco-regional databases. cohort-specific relative risks (RR) of an increase of 1 1 standard deviation of log antibody level and corresponding 95% confidence interval (CI), and finally combined them in random-effects meta-analyses. Results A 6-month serological response was detected in 99.6% of HCWs. Female sex (RR 1.10, 95%CI 1.00-1.21), past infection (RR 2.26, 95%CI 1.73-2.95) and two vaccine doses (RR 1.50, 95%CI 1.22-1.84) predicted higher IgG titer, contrary to interval Refametinib<\/a> since last dose (RR for 10-day increase 0.94, 95%CI 0.91-0.97) and age (RR for 10-year increase 0.87, 95%CI 0.83-0.92). M-RNA-based vaccines (p<0.001) and heterologous vaccination (RR 2.46, 95%CI 1.87-3.24, one cohort) were associated with increased antibody levels. Conclusions Female gender, young age, past infection, two vaccine doses, and m-RNA and heterologous vaccination predicted higher antibody level at 6 months. These results corroborate previous findings and offer valuable data for comparison with trends observed with longer follow-ups. Keywords: vaccine, COVID C 19, serology, health care workers (HCW), immune response Introduction COVID-19 represents one of the major acute infectious threats of the XXI century. The pandemic nature of COVID-19 infection rose several challenges, leading to deep daily life changes in most populations Refametinib of the world (1). The pandemic implied an urgent need for vaccines development, which first entered in use in December 2020 (2). The mRNA mechanism of newly developed vaccines, namely Comirnaty (BioNTech\/Pfizer) and Spikevax (Moderna), has been largely debated. mRNA Refametinib vaccines were known to be versatile and rapid to design even before COVID pandemic (3), with the benefit of a short manufacturing time matched with high efficacy, and to be overall safe (4). In many countries, health care workers (HCWs) were among the first population groups to be recommended the vaccination, given their high exposure to COVID-19 infection (5). Once vaccines were recommended at mass level against infection spreading (6), one of the main issues became to determine their effectiveness against COVID-19 infection. Preliminary data showed that vaccines were effective against the development of symptoms and reduced the risk of infection (2, 4, 7). Indeed, immune responsiveness is necessary for a vaccine to be effective towards its target (8). The quantity of antibodies against the targeted microorganism depends on the type of vaccine and can be interpreted as an index of effectiveness of a vaccine, and the type of induced antibodies (9). In addition, subject-related factors can influence the serological response: health conditions such as immunosuppression, diabetes, autoimmune diseases and cardiovascular diseases have been described as inversely related to immune response after COVID-vaccine, while young age and female sex have been directly related to it. Baseline seropositivity was also reported as predictor of higher serological response after vaccination (10, 11). Despite several studies were conducted in occupational settings, little information is available for different job categories, where exposure to infection and subsequent development of natural antibodies may mediate the different serological level after vaccination, in particular among HCWs (12). To date, few studies have Refametinib evaluated the longitudinal immune response to COVID-19 vaccines (13C16). A recent publication reviewed the available data on duration of vaccine effectiveness, which was assessed to decrease by about 20-30% within 6 months (17). ORCHESTRA is a multicenter prospective cohort including HCWs from multiple countries (18). This analysis within ORCHESTRA is focused on the characteristics of anti-Sars-CoV-2 Spike immune response to COVID-19 vaccines at 6 months since the 1rst dose. Previous publications based on ORCHESTA dataset reported the kinetics of antibody response to COVID-19 vaccination (19), the predictors of immunological response to vaccination (20), as well as the predictors of COVID-19 infection in HCWs by occupational factors such as use of personal protective equipment (PPE) and job title (12). ORCHESTRA provides unique data on different job titles, COVID-19 history of the HCWs, and type of vaccine administered. We aimed at identifying the predictors of immune response up to 6 months from vaccination, by exploring HCW-related and vaccination-related characteristics. Methods ORCHESTRA comprises a prospective multicenter cohort of HCWs employed in hospitals in multiple PB1<\/a> countries (18) including over 60,000 HCWs. This analysis includes HCWs from one center in Germany.<\/p>\n","protected":false},"excerpt":{"rendered":"

\ufeffData on sociodemographic characteristics, results of PCR testing, and vaccination status, including date of vaccination doses and type, were either abstracted from medical surveillance records or collected using questionnaires or ongoing loco-regional databases. cohort-specific relative risks (RR) of an increase of 1 1 standard deviation of log antibody level and corresponding 95% confidence interval (CI), […]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[19],"tags":[],"class_list":["post-720","post","type-post","status-publish","format-standard","hentry","category-steroidogenic-factor-1"],"yoast_head":"\n\ufeffData on sociodemographic characteristics, results of PCR testing, and vaccination status, including date of vaccination doses and type, were either abstracted from medical surveillance records or collected using questionnaires or ongoing loco-regional databases - 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