YC, LK, XS, ME, DJA and AL performed and interpreted the experiments

YC, LK, XS, ME, DJA and AL performed and interpreted the experiments. activation in fibroblasts are enhanced. Inhibiting TSP1 activity reduced the elevated activation of MEK/ERK and expression of important fibrogenic proteins. TSP1 also blocked platelet-derived growth factor (PDGF)-induced contractile activity and MEK/ERK activation. Conclusions TSP1 is usually a key mediator of matrix contraction of […]