Complexes immunoprecipitated with Myc- or HA-tagged DYRK1A were blended with 1?g recombinant tau protein, the kinase reaction buffer, 0

Complexes immunoprecipitated with Myc- or HA-tagged DYRK1A were blended with 1?g recombinant tau protein, the kinase reaction buffer, 0.2?mM Na3VO4, and 10?M ATP. from the PP2C category of Ser/Thr proteins phosphatases, in HEK293?cells. We discovered that PPM1B dephosphorylates DYRK1A at Ser258, adding to the inhibition of DYRK1A activity. Furthermore, PPM1B-mediated dephosphorylation of DYRK1A decreased tau […]

The regions of interest were also selected using the support of a specialist histopathologist (2nd row from top), then processed for colour threshold adjustment using HSB and red as threshold colour (3rd row from top) and, finally all of the images were transformed to binary colours where the regions of interest come in solid dark colour (bottom row)

The regions of interest were also selected using the support of a specialist histopathologist (2nd row from top), then processed for colour threshold adjustment using HSB and red as threshold colour (3rd row from top) and, finally all of the images were transformed to binary colours where the regions of interest come in solid dark […]