However, the Y331F Becn1 complemented organizations showed high caspase-3/PARP apoptotic signaling pathway activation

However, the Y331F Becn1 complemented organizations showed high caspase-3/PARP apoptotic signaling pathway activation. mechanisms underlying the link between autophagy and extracellular cytokines remain to be elucidated. In the present study, we demonstrate that IL-6 activates autophagy through the IL-6/JAK2/BECN1 pathway and promotes chemotherapy resistance in colorectal malignancy (CRC). Mechanistically, IL-6 causes the connection between JAK2 […]